Research On Highly Biocompatible Polyethersulfone Hollow Fiber Hemodialysis Membrane

In order to remove harmful substances and water from the blood and regulate human electrolytes, patients with renal failure need to use hollow fiber membrane type artificial dialyzers. During hemodialysis, the blood contains blood cells, proteins and other components, which easily lead to a decrease in membrane flux. Seeking a new type of dialysis membrane that is not easy to adsorb proteins, is not easy to form a coagulated protein layer on the membrane surface, and has a smooth membrane surface is the main direction of future research. At present, the types of dialysis membrane materials are constantly changing, but there are still defects in removing β_2~-microglobulin and biocompatibility. This experiment focuses on the structural properties and dialysis properties of polyethersulfone membrane materials. In this paper, polyethersulfone hollow fiber dialysis membranes are spun by dry-wet spinning process, and the structure of hollow fiber membranes with different wall thicknesses and inner diameters and the dialysis performance of the developed dialyzers are studied to determine the best spinning process; the effects of dialysis membrane area, simulated fluid and dialysate flow rates, and solute concentration gradients on membrane dialysis performance are studied to determine the best dialysis conditions. The treated hollow fiber membrane was cast into small components, and the pure water flux, burst pressure, tensile elongation and breaking strength of the membrane were tested using a laboratory-made device. The hollow fiber membrane was encapsulated into a dialyzer by centrifugal casting. Lysozyme was used instead of β_2~-microglobulin, and bovine serum albumin was used instead of human serum albumin. A simulated liquid composed of pure water, urea, lysozyme and bovine serum albumin was prepared. This simulated liquid was used to replace the patient's blood to evaluate the dialysis performance of the polyethersulfone hollow fiber membrane dialyzer developed in this paper. The results showed that when the content of the additive polyethylene glycol was 27.6wt%, the mechanical properties of the membrane were better. The clearance rate of urea in the simulated fluid of the hollow fiber membrane dialyzers with different wall thicknesses can reach more than 64%, and the difference is not big. The retention rate of bovine serum albumin can reach more than 98%. There are some differences in the clearance rate of lysozyme. The smaller the wall thickness, the higher the clearance rate. The membrane with a wall thickness of 10μm has a clearance rate of 29% for lysozyme. The clearance rate of urea of ​​the dialyzers with different fiber inner diameters is about 80%. The dialyzer with a fiber inner diameter of 0.26mm has the highest clearance rate of urea, reaching 88.6%. The clearance rate of lysozyme varies greatly. The smaller the inner diameter, the higher the clearance rate. The dialyzer with an inner diameter of 0.26mm has a clearance rate of 62.8% for lysozyme. It has little effect on the retention of bovine serum albumin, and the retention rate can reach more than 98%. Increasing the area of ​​the dialysis membrane, increasing the flow rate of the simulated fluid and dialysate, and increasing the solute concentration gradient can increase the clearance rate of lysozyme and urea, and has almost no effect on the retention of bovine serum albumin.